Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003061)
Formula Reactant Atazanavir Product Atazanavir metabolite M14
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003055 Atazanavir Atazanavir metabolite M1 Oxidation - Dealkylation Atazanavir [1]
MR003060 Atazanavir Atazanavir metabolite M13 Hydrolysis - Hydrolysis Atazanavir [1]
MR003062 Atazanavir Atazanavir metabolite M15 Unclear Atazanavir [1]
MR003063 Atazanavir Atazanavir metabolite M15' Oxidation - Dealkylation Atazanavir [1]
MR003047 Atazanavir Atazanavir metabolite M2 Oxidation - Monohydroxylation Atazanavir [1]
MR003057 Atazanavir Atazanavir metabolite M3 Oxidation - Monohydroxylation Atazanavir [1]
MR003058 Atazanavir Atazanavir metabolite M4 Oxidation - Monohydroxylation Atazanavir [1]
MR003059 Atazanavir Atazanavir metabolite M5 Oxidation - Monohydroxylation Atazanavir [1]
References
1 CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism Drug Metab Dispos. 2011 Mar;39(3):394-401. doi: 10.1124/dmd.110.036327.

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