Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003062)
Formula
SVG example
Reactant Atazanavir Product Atazanavir metabolite M15
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003055 Atazanavir Atazanavir metabolite M1 Oxidation - Dealkylation Atazanavir [1]
MR003060 Atazanavir Atazanavir metabolite M13 Hydrolysis - Hydrolysis Atazanavir [1]
MR003061 Atazanavir Atazanavir metabolite M14 Hydrolysis - Hydrolysis Atazanavir [1]
MR003063 Atazanavir Atazanavir metabolite M15' Oxidation - Dealkylation Atazanavir [1]
MR003047 Atazanavir Atazanavir metabolite M2 Oxidation - Monohydroxylation Atazanavir [1]
MR003057 Atazanavir Atazanavir metabolite M3 Oxidation - Monohydroxylation Atazanavir [1]
MR003058 Atazanavir Atazanavir metabolite M4 Oxidation - Monohydroxylation Atazanavir [1]
MR003059 Atazanavir Atazanavir metabolite M5 Oxidation - Monohydroxylation Atazanavir [1]
References
1 CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism Drug Metab Dispos. 2011 Mar;39(3):394-401. doi: 10.1124/dmd.110.036327.

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