Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003137)
Formula
SVG example
N-Dealkylation
Reactant Delavirdine mesylate Product N-desalkyl delavirdine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003140 Delavirdine mesylate Delavirdine mesylate MET-10 Unclear Delavirdine mesylate [1]
MR003141 Delavirdine mesylate Delavirdine mesylate MET-12 Unclear Delavirdine mesylate [1]
MR003138 Delavirdine mesylate Delavirdine mesylate MET-16 Oxidation - Hydroxylation; Glucuronidation Delavirdine mesylate [1]
MR003139 Delavirdine mesylate Delavirdine mesylate MET-17 Conjugation - Glucuronidation Delavirdine mesylate [1]
MR003133 Delavirdine mesylate Delavirdine mesylate MET-7 Oxidation - Hydroxylation Delavirdine mesylate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003130 N-desalkyl delavirdine Delavirdine mesylate MET-15d Oxidation - Hydroxylation Delavirdine mesylate [1]
MR003128 N-desalkyl delavirdine Delavirdine mesylate MET-4a Conjugation - Sulfation Delavirdine mesylate [1]
MR003129 N-desalkyl delavirdine Delavirdine mesylate MET-4c Conjugation - Glucuronidation Delavirdine mesylate [1]
MR003131 N-desalkyl delavirdine Delavirdine mesylate MET-4d Conjugation - Sulfation Delavirdine mesylate [1]
References
1 Identification of the metabolites of the HIV-1 reverse transcriptase inhibitor delavirdine in monkeys Drug Metab Dispos. 1997 Jul;25(7):814-27.

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