Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003245)
Formula Reactant DM-6705 Product D6076
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003251 Delamanid DM-6705 Unclear Delamanid [1], [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003244 DM-6705 DM-6704 Unclear Delamanid [1]
References
1 Pharmacokinetics and metabolism of delamanid, a novel anti-tuberculosis drug, in animals and humans: importance of albumin metabolism in vivo. Drug Metab Dispos. 2015 Aug;43(8):1267-76.
2 Liquid chromatography-tandem mass spectrometry analysis of delamanid and its metabolite in human cerebrospinal fluid using protein precipitation and on-line solid-phase extraction. J Pharm Biomed Anal. 2023 Apr 1;227:115281. doi: 10.1016/j.jpba.2023.115281.
3 Relative bioavailability of delamanid 50?mg tablets dispersed in water in healthy adult volunteers. Br J Clin Pharmacol. 2023 Jan 24. doi: 10.1111/bcp.15672.
4 Assessing Prolongation of the Corrected QT?Interval with Bedaquiline and Delamanid Coadministration to Predict the Cardiac Safety?of Simplified Dosing Regimens. Clin Pharmacol Ther. 2022 Oct;112(4):873-881. doi: 10.1002/cpt.2685.

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