Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003263)
Formula Reactant 12-hydroxynevirapine Product 12-sulphoxy-nevirapine
Reactant Info Product Info
Metabolic Enzyme Sulfotransferase (SULT) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003269 Nevirapine 12-hydroxynevirapine Oxidation - Hydroxylation Nevirapine [1], [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003265 12-hydroxynevirapine 12-hydroxynevirapine glucuronide metabolite Unclear Nevirapine [2]
MR003264 12-hydroxynevirapine 4-carboxynevirapine Unclear Nevirapine [2]
References
1 Disposition and biotransformation of the antiretroviral drug nevirapine in humans Drug Metab Dispos. 1999 Aug;27(8):895-901.
2 Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions J Antimicrob Chemother. 2014 Feb;69(2):476-82. doi: 10.1093/jac/dkt359.
3 Sulfation of 12-hydroxy-nevirapine by human SULTs and the effects of genetic polymorphisms of SULT1A1 and SULT2A1. Biochem Pharmacol. 2022 Oct;204:115243. doi: 10.1016/j.bcp.2022.115243.

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