Details of Drug-Metabolizing Enzyme (DME)
| General Information of DME (ID: DMEN061) | |||||
|---|---|---|---|---|---|
| DME Name | Sulfotransferase (SULT), . | ||||
| Gene Name | SULT | ||||
| Click to Show/Hide the Molecular/Functional Data (Sequence/Structure/Pathway/Function) of This DME | |||||
| Full List of Drug(s) Metabolized by This DME | |||||
|---|---|---|---|---|---|
| Drugs Approved by FDA | Click to Show/Hide the Full List of Drugs: 6 Drugs | ||||
Fospropofol disodium |
Drug Info | Approved | Monitored anaesthesia care | ICD11: N.A. | [1] |
Lapatinib ditosylate |
Drug Info | Approved | Breast cancer | ICD11: 2C60 | [2] |
Nevirapine |
Drug Info | Approved | Human immunodeficiency virus infection | ICD11: 1C60 | [3] |
Methyldopate Hydrochloride |
Drug Info | Approved | Hypertension | ICD11: BA00-BA04 | [4] |
Troglitazone |
Drug Info | Approved | Diabetes mellitus | ICD11: 5A10 | [5] |
3,4-Dihydroxycinnamic Acid |
Drug Info | Phase 4 | Thrombocytopenia | ICD11: 3B64 | [6] |
| Drugs in Phase 2 Clinical Trial | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
INX-189 |
Drug Info | Phase 2 | Hepatitis C virus infection | ICD11: 1E50-1E51 | [7] |
| Drugs in Phase 1 Clinical Trial | Click to Show/Hide the Full List of Drugs: 1 Drugs | ||||
STX 64 |
Drug Info | Phase 1 | Prostate cancer | ICD11: 2C82 | [8] |
| References | |||||
|---|---|---|---|---|---|
| 1 | Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects | ||||
| 2 | Detoxication versus Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib Drug Metab Dispos. 2021 Mar;49(3):233-244. doi: 10.1124/dmd.120.000236. | ||||
| 3 | Sulfation of 12-hydroxy-nevirapine by human SULTs and the effects of genetic polymorphisms of SULT1A1 and SULT2A1. Biochem Pharmacol. 2022 Oct;204:115243. doi: 10.1016/j.bcp.2022.115243. | ||||
| 4 | DrugBank(Pharmacology-Metabolism):Methyldopate Hydrochloride | ||||
| 5 | Acute pancreatitis in a patient treated with imatinib and gefitinib. J Oncol Pharm Pract. 2021 Jun;27(4):980-983. doi: 10.1177/1078155220949639. | ||||
| 6 | Absorption, disposition, metabolism, and excretion of [3-(14)C]caffeic acid in rats | ||||
| 7 | In Vitro Metabolite Formation in Human Hepatocytes and Cardiomyocytes and Metabolism and Tissue Distribution in Monkeys of the 2'-C-Methylguanosine Prodrug BMS-986094 : Potential Role in Clinical Cardiovascular Toxicity | ||||
| 8 | In vitro metabolism of irosustat, a novel steroid sulfatase inhibitor: interspecies comparison, metabolite identification, and metabolic enzyme identification | ||||
| 9 | Genistein: Dual Role in Women's Health | ||||
| 10 | FDA Label of Brexanolone | ||||
| 11 | Interaction of Chrysin and Its Main Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide with Serum Albumin | ||||
| 12 | Resveratrol Inhibits Key Steps of Steroid Metabolism in a Human Estrogen-Receptor Positive Breast Cancer Model: Impact on Cellular Proliferation Front Pharmacol. 2018 Jul 10;9:742. doi: 10.3389/fphar.2018.00742. | ||||
| 13 | Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. | ||||
| 14 | Crude Edible Fig (Ficus carica) Leaf Extract Prevents Diethylstilbestrol (DES)-Induced DNA Strand Breaks in Single-Cell Gel Electrophoresis (SCGE)/Comet Assay: Literature Review and Pilot Study J Bioequivalence Bioavailab. 2019;11(2):19-28. doi: 10.35248/0975-0851.19.11.389. | ||||
| 15 | Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24. | ||||
| 16 | Comparative In vitro Metabolism of Enflicoxib in Dogs, Rats, and Humans: Main Metabolites and Proposed Metabolic Pathways | ||||
| 17 | Clinical pharmacokinetics and drug-drug interactions of Elbasvir/Grazoprevir. Eur J Drug Metab Pharmacokinet. 2018 Oct;43(5):509-531. | ||||
| 18 | Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite. Toxicol Lett. 2001 Dec 15;125(1-3):117-23. | ||||
| 19 | Benzylic alcohols as stereospecific substrates and inhibitors for aryl sulfotransferase. Chirality. 1991;3(2):104-11. | ||||
| 20 | Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans Biochem Pharmacol. 2013 Apr 15;85(8):1195-202. doi: 10.1016/j.bcp.2013.01.031. | ||||
| 21 | Case Study 11: Considerations for Enzyme Mapping Experiments-Interaction Between the Aldehyde Oxidase Inhibitor Hydralazine and Glutathione. Methods Mol Biol. 2021;2342:809-823. doi: 10.1007/978-1-0716-1554-6_30. | ||||
| 22 | [Metabolism of lomerizine hydrochloride (KB-2796) in rats] | ||||
| 23 | THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS | ||||
| 24 | Clinical pharmacokinetics of methyldopa | ||||
| 25 | Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity. Clin Pharmacol Ther. 1985 Mar;37(3):308-15. | ||||
| 26 | Differences in nevirapine biotransformation as a factor for its sex-dependent dimorphic profile of adverse drug reactions J Antimicrob Chemother. 2014 Feb;69(2):476-82. doi: 10.1093/jac/dkt359. | ||||
| 27 | Preclinical pharmacokinetics of triptolide: a potential antitumor drug. Curr Drug Metab. 2019;20(2):147-154. | ||||
| 28 | Ferulic Acid: therapeutic potential through its antioxidant property | ||||
| 29 | Liquid chromatography-tandem mass spectrometry analysis of anisodamine and its phase I and II metabolites in rat urine | ||||
| 30 | Pharmacokinetics of triamterene and its metabolite in man J Pharmacokinet Biopharm. 1982 Oct;10(5):507-23. doi: 10.1007/BF01059034. | ||||
| 31 | Pharmacokinetics of triamterene Clin Exp Hypertens A. 1983;5(2):249-69. doi: 10.3109/10641968309048825. | ||||
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