Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003329)
Formula
SVG example
Oxidation
Reactant 5-hydroxy pirfenidone Product 5-Carboxy pirfenidone
Reactant Info Product Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003332 Pirfenidone 5-hydroxy pirfenidone Oxidation - 5-Hydroxylation Pirfenidone [1], [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003331 5-hydroxy pirfenidone Acetoxypirfenidone Unclear Pirfenidone [1], [2], [3]
MR003330 5-hydroxy pirfenidone Hydroxy pirfenidone glucuronide Unclear Pirfenidone [1], [2], [3]
References
1 Pharmacokinetic evaluation of tissue distribution of pirfenidone and its metabolites for idiopathic pulmonary fibrosis therapy Biopharm Drug Dispos. 2015 May;36(4):205-15. doi: 10.1002/bdd.1932.
2 Pharmacokinetic and pharmacometabolomic study of pirfenidone in normal mouse tissues using high mass resolution MALDI-FTICR-mass spectrometry imaging Histochem Cell Biol. 2016 Feb;145(2):201-11. doi: 10.1007/s00418-015-1382-7.
3 Pharmacokinetics and metabolism of intravenous pirfenidone in sheep Biopharm Drug Dispos. 2008 Mar;29(2):119-26. doi: 10.1002/bdd.595.

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