Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003330)
Formula Reactant 5-hydroxy pirfenidone Product Hydroxy pirfenidone glucuronide
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003332 Pirfenidone 5-hydroxy pirfenidone Oxidation - 5-Hydroxylation Pirfenidone [1], [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003329 5-hydroxy pirfenidone 5-Carboxy pirfenidone Oxidation - Oxidation Pirfenidone [1], [2], [3]
MR003331 5-hydroxy pirfenidone Acetoxypirfenidone Unclear Pirfenidone [1], [2], [3]
References
1 Pharmacokinetic evaluation of tissue distribution of pirfenidone and its metabolites for idiopathic pulmonary fibrosis therapy Biopharm Drug Dispos. 2015 May;36(4):205-15. doi: 10.1002/bdd.1932.
2 Pharmacokinetic and pharmacometabolomic study of pirfenidone in normal mouse tissues using high mass resolution MALDI-FTICR-mass spectrometry imaging Histochem Cell Biol. 2016 Feb;145(2):201-11. doi: 10.1007/s00418-015-1382-7.
3 Pharmacokinetics and metabolism of intravenous pirfenidone in sheep Biopharm Drug Dispos. 2008 Mar;29(2):119-26. doi: 10.1002/bdd.595.

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