Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003333)
Formula
SVG example
Methylation
Reactant Paroxetine catechol Product (-)-trans-4-[4-(4'-Fluorophenyl)-3-piperidinylmethoxy]-2-methoxyphenol
Reactant Info Product Info
Metabolic Type Conjugation - Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003337 Paroxetine hydrochloride Paroxetine catechol Unclear Paroxetine hydrochloride [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003336 Paroxetine catechol (3S-trans)-5-[[4-(4-Fluorophenyl)-3-piperidinyl]methoxy]-2-methoxyphenol Conjugation - Methylation Paroxetine hydrochloride [2]
MR003334 Paroxetine catechol 4-(4-Fluorophenyl)-3-(4-hydroxy-3-methoxyphenoxymethyl)piperidine Conjugation - Methylation Paroxetine hydrochloride [2]
MR003335 Paroxetine catechol 4-(4-Fluorophenyl)-3-(4-methoxy-3-hydroxyphenoxymethyl)piperidine Conjugation - Methylation Paroxetine hydrochloride [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Identification of cytochrome P450 isoforms involved in the metabolism of paroxetine and estimation of their importance for human paroxetine metabolism using a population-based simulator. Drug Metab Dispos. 2010 Mar;38(3):376-85.

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