Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003337)
Formula
CYP2D6 ...
SVG example
Reactant Paroxetine hydrochloride Product Paroxetine catechol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003333 Paroxetine catechol (-)-trans-4-[4-(4'-Fluorophenyl)-3-piperidinylmethoxy]-2-methoxyphenol Conjugation - Methylation Paroxetine hydrochloride [1]
MR003336 Paroxetine catechol (3S-trans)-5-[[4-(4-Fluorophenyl)-3-piperidinyl]methoxy]-2-methoxyphenol Conjugation - Methylation Paroxetine hydrochloride [1]
MR003334 Paroxetine catechol 4-(4-Fluorophenyl)-3-(4-hydroxy-3-methoxyphenoxymethyl)piperidine Conjugation - Methylation Paroxetine hydrochloride [1]
MR003335 Paroxetine catechol 4-(4-Fluorophenyl)-3-(4-methoxy-3-hydroxyphenoxymethyl)piperidine Conjugation - Methylation Paroxetine hydrochloride [1]
References
1 Identification of cytochrome P450 isoforms involved in the metabolism of paroxetine and estimation of their importance for human paroxetine metabolism using a population-based simulator. Drug Metab Dispos. 2010 Mar;38(3):376-85.

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