Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003342)
Formula Reactant Safinamide mesylate Product O-debenzylated safinamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003341 Safinamide mesylate Safinamide acid Unclear Safinamide mesylate [1]
MR003340 Safinamide mesylate Safinamide mesylate Oxidation - Dealkylation Safinamide mesylate [1]
MR003338 Safinamide mesylate Safinamide mesylate carboxylic acid Oxidation - Oxidation Safinamide mesylate [1], [2]
References
1 Disposition and metabolism of safinamide, a novel drug for Parkinson's disease, in healthy male volunteers. Pharmacology. 2013;92(3-4):207-16.
2 DailyMed : Safinamide mesylate

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