Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003362)
Formula
SVG example
Cysteine-Glycine Condensation
Reactant Apalutamide Product Apalutamide metabolite M10
Reactant Info Product Info
Metabolic Type Conjugation - Cysteine-Glycine Condensation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003366 Apalutamide Apalutamide metabolite M13 Hydrolysis - Nitrile Hydrolysis Apalutamide [1]
MR003365 Apalutamide Apalutamide metabolite M19 Unclear Apalutamide [1]
MR003368 Apalutamide Apalutamide metabolite M2 Oxidation - Oxidation; Desulfuration Apalutamide [1]
MR003364 Apalutamide Apalutamide metabolite M4 Hydrolysis - Amide Hydrolysis Apalutamide [1]
MR003367 Apalutamide Apalutamide metabolite M8 Oxidation - Oxidation Apalutamide [1]
MR003363 Apalutamide Apalutamide metabolite M9 Unclear Apalutamide [1]
MR003361 Apalutamide N-desmethyl apalutamide Oxidation - N-Demethylation Apalutamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003349 Apalutamide metabolite M10 Apalutamide metabolite M12 Unclear Apalutamide [1]
MR003350 Apalutamide metabolite M10 Apalutamide metabolite M9 Conjugation - Cysteine Condensation Apalutamide [1]
References
1 Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes Drug Metab Dispos. 2019 May;47(5):453-464. doi: 10.1124/dmd.118.084517.

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