Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003361)
Formula
CYP2C8 ...
SVG example
N-Demethylation
Reactant Apalutamide Product N-desmethyl apalutamide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003362 Apalutamide Apalutamide metabolite M10 Conjugation - Cysteine-Glycine Condensation Apalutamide [1]
MR003366 Apalutamide Apalutamide metabolite M13 Hydrolysis - Nitrile Hydrolysis Apalutamide [1]
MR003365 Apalutamide Apalutamide metabolite M19 Unclear Apalutamide [1]
MR003368 Apalutamide Apalutamide metabolite M2 Oxidation - Oxidation; Desulfuration Apalutamide [1]
MR003364 Apalutamide Apalutamide metabolite M4 Hydrolysis - Amide Hydrolysis Apalutamide [1]
MR003367 Apalutamide Apalutamide metabolite M8 Oxidation - Oxidation Apalutamide [1]
MR003363 Apalutamide Apalutamide metabolite M9 Unclear Apalutamide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003343 N-desmethyl apalutamide Apalutamide metabolite M12 Unclear Apalutamide [1]
MR003344 N-desmethyl apalutamide Apalutamide metabolite M14 Unclear Apalutamide [1]
MR003345 N-desmethyl apalutamide Apalutamide metabolite M4 Unclear Apalutamide [1]
MR003346 N-desmethyl apalutamide Apalutamide metabolite M5 Unclear Apalutamide [1]
References
1 Apalutamide Absorption, Metabolism, and Excretion in Healthy Men, and Enzyme Reaction in Human Hepatocytes Drug Metab Dispos. 2019 May;47(5):453-464. doi: 10.1124/dmd.118.084517.

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