Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003371)
Formula
SVG example
4'-Hydroxylation
Reactant Aceclofenac Product 4'-hydroxyaceclofenac
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - 4'-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003373 Aceclofenac 5-hydroxyaceclofenac Oxidation - 5-Hydroxylation Aceclofenac [1]
MR003372 Aceclofenac Diclofenac Hydrolysis - Hydrolysis Aceclofenac [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003369 4'-hydroxyaceclofenac 4'-hydroxydiclofenac Unclear Aceclofenac [3]
References
1 DrugBank(Pharmacology-Metabolism)Aceclofenac
2 Aceclofenac in the management of inflammatory pain Expert Opin Pharmacother. 2004 Jun;5(6):1347-57. doi: 10.1517/14656566.5.6.1347.
3 Modeling of aceclofenac metabolism to major metabolites in healthy volunteers Drug Metab Pharmacokinet. 2016 Dec;31(6):458-463. doi: 10.1016/j.dmpk.2016.10.001.

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