Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003374)
Formula
SVG example
N-Demethylation
Reactant O-Desmethyltramadol Product N,O-didesmethyltramadol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003380 Tramadol hydrochloride O-Desmethyltramadol Oxidation - O-Demethylation Tramadol hydrochloride [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003375 O-Desmethyltramadol O-Desmethyl-tramado glucuronide metabolite Oxidation - N-Demethylation Tramadol hydrochloride [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003377 N-Desmethyltramadol N,O-didesmethyltramadol Oxidation - O-Demethylation Tramadol hydrochloride [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003376 N,O-didesmethyltramadol N,N,O-tridesmethyl-tramadol Unclear Tramadol hydrochloride [4]
References
1 Trends in Tramadol: Pharmacology, Metabolism, and Misuse Anesth Analg. 2017 Jan;124(1):44-51. doi: 10.1213/ANE.0000000000001683.
2 Simultaneous LC-MS/MS quantification of oxycodone, tramadol and fentanyl and their metabolites (noroxycodone, oxymorphone, O- desmethyltramadol, N- desmethyltramadol, and norfentanyl) in human plasma and whole blood collected via venepuncture and volumetric absorptive micro sampling. J Pharm Biomed Anal. 2021 Sep 5;203:114171. doi: 10.1016/j.jpba.2021.114171.
3 DrugBank : Tramadol hydrochloride
4 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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