Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003401)
Formula
SVG example
Oxidation
Reactant Febuxostat Product Febuxostat metabolite 67M-3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A1 (CYP1A1) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003402 Febuxostat Febuxostat acyl-glucuronide Conjugation - Conjugation Febuxostat [1]
MR003399 Febuxostat Febuxostat metabolite 67M-1 Oxidation - Oxidation Febuxostat [1]
MR003400 Febuxostat Febuxostat metabolite 67M-2 Oxidation - Oxidation Febuxostat [1]
References
1 In vitro drug-drug interaction studies with febuxostat, a novel non-purine selective inhibitor of xanthine oxidase: plasma protein binding, identification of metabolic enzymes and cytochrome P450 inhibition. Xenobiotica. 2008 May;38(5):496-510.

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