Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003407)
Formula
SVG example
N-Demethylation
Reactant Diphenylpyraline Product N-monodesmethyl Levomepromazine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003410 Diphenylpyraline . Oxidation - Hydroxylation Diphenylpyraline [1]
MR003408 Diphenylpyraline Levomepromazine glucuronide Conjugation - Glucuronidation Diphenylpyraline [2]
MR003406 Diphenylpyraline Levomepromazine sulfoxide Oxidation - Sulfoxidation Diphenylpyraline [3], [1]
MR003409 Diphenylpyraline O-monodesmethyl Levomepromazine Oxidation - O-Demethylation Diphenylpyraline [1]
References
1 The influence of amitriptyline and carbamazepine on levomepromazine metabolism in human liver: an in vitro study Pharmacol Rep. 2014 Dec;66(6):1122-6. doi: 10.1016/j.pharep.2014.07.012.
2 DrugBank(Pharmacology-Metabolism)Diphenylpyraline
3 Pharmacokinetics and first-pass metabolism of levomepromazine in the rat Acta Pharmacol Toxicol (Copenh). 1982 Feb;50(2):148-54. doi: 10.1111/j.1600-0773.1982.tb00956.x.

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