Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003487)
Formula
SVG example
Hydroxylation
Reactant Valdecoxib metabolite M1 Product Valdecoxib metabolite M3
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003302 Valdecoxib Valdecoxib metabolite M1 Oxidation - Methyl-Hydroxylation Valdecoxib [1], [2]
MR003485 Valdecoxib Valdecoxib metabolite M1 Oxidation - Methyl-Hydroxylation Parecoxib [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003296 Valdecoxib metabolite M1 Valdecoxib metabolite M1-G Unclear Valdecoxib [2]
MR003295 Valdecoxib metabolite M1 Valdecoxib metabolite M4 Oxidation - Oxidation Valdecoxib [2]
MR003293 Valdecoxib metabolite M1 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Valdecoxib [2]
MR003495 Valdecoxib metabolite M1 Valdecoxib metabolite M1-G Conjugation - Glucuronidation Parecoxib [2]
MR003489 Valdecoxib metabolite M1 Valdecoxib metabolite M4 Oxidation - Oxidation Parecoxib [2], [1]
MR003486 Valdecoxib metabolite M1 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Parecoxib [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003299 Valdecoxib metabolite M9 Valdecoxib metabolite M3 Unclear Valdecoxib [1]
MR003492 Valdecoxib metabolite M9 Valdecoxib metabolite M3 Unclear Parecoxib [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003297 Valdecoxib metabolite M3 Valdecoxib metabolite M3-G Oxidation - S-Oxidation Valdecoxib [1]
MR014140 Valdecoxib metabolite M3 Valdecoxib metabolite M3-G Oxidation - S-Oxidation Parecoxib [1]
References
1 Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human Drug Metab Dispos. 2002 Sep;30(9):1013-21. doi: 10.1124/dmd.30.9.1013.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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