Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003495)
Formula
UGT
SVG example
Glucuronidation
Reactant Valdecoxib metabolite M1 Product Valdecoxib metabolite M1-G
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003302 Valdecoxib Valdecoxib metabolite M1 Oxidation - Methyl-Hydroxylation Valdecoxib [1], [2]
MR003485 Valdecoxib Valdecoxib metabolite M1 Oxidation - Methyl-Hydroxylation Parecoxib [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003294 Valdecoxib metabolite M1 Valdecoxib metabolite M3 Oxidation - Hydroxylation Valdecoxib [1]
MR003295 Valdecoxib metabolite M1 Valdecoxib metabolite M4 Oxidation - Oxidation Valdecoxib [2]
MR003293 Valdecoxib metabolite M1 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Valdecoxib [2]
MR003487 Valdecoxib metabolite M1 Valdecoxib metabolite M3 Oxidation - Hydroxylation Parecoxib [1]
MR003489 Valdecoxib metabolite M1 Valdecoxib metabolite M4 Oxidation - Oxidation Parecoxib [2], [1]
MR003486 Valdecoxib metabolite M1 Valdecoxib metabolite M5 Oxidation - Methyl-Hydroxylation Parecoxib [2]
References
1 Disposition of a specific cyclooxygenase-2 inhibitor, valdecoxib, in human Drug Metab Dispos. 2002 Sep;30(9):1013-21. doi: 10.1124/dmd.30.9.1013.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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