Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003606)
Formula
SVG example
Hydrolyzationn
Reactant Cibenzoline Product p-hydroxycibenzoline
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003610 Cibenzoline 2-(2,2-diphenylcyclopropyl)-1H-imidazole Unclear Cibenzoline [1]
MR003607 Cibenzoline 4,5-dehydrocibenzoline Oxidation - Hydrolyzationn Cibenzoline [2]
MR003608 Cibenzoline Cibenzoline Metabolite M3 Oxidation - Hydrolyzationn Cibenzoline [2]
MR003609 Cibenzoline Cibenzoline Metabolite M4 Oxidation - Hydrolyzationn Cibenzoline [2]
References
1 Biotransformation of cibenzoline to 2-(2,2-diphenylcyclopropyl)-1H-imidazole
2 Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A. Drug Metab Dispos. 2000 Sep;28(9):1128-34.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.