Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003714)
Formula
SVG example
Ester hydrolysis
Reactant LCZ-696 Product Sacubitril
Reactant Info Product Info
Metabolic Type Hydrolysis - Ester hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003724 LCZ-696 Valsartan Hydrolysis - Ester hydrolysis LCZ-696 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003715 Sacubitril LBQ657 Hydrolysis - Ester hydrolysis LCZ-696 [2], [3], [1]
MR003721 Sacubitril LCZ-696 Metabolite M2 Unclear LCZ-696 [1]
MR003723 Sacubitril LCZ-696 Metabolite M3 Unclear LCZ-696 [1]
References
1 Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects
2 Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi)
3 Dicarboxylic acid dipeptide neutral endopeptidase inhibitors

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