Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003724)
Formula	Ester hydrolysis
	Reactant	LCZ-696	Product	Valsartan
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Hydrolysis - Ester hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR003714	LCZ-696	Sacubitril	Hydrolysis - Ester hydrolysis	LCZ-696	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR010567	LCZ696	Valsartan	Unclear - Unclear	LCZ696	[2]

References
1	Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects
2	An evaluation of the fixed-dose combination sacubitril/valsartan for the treatment of arterial hypertension

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