Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003750)
Formula Reactant LY-2484595 Metabolite M2 Product LY-2484595 Metabolite M6
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003747 LY-2484595 LY-2484595 Metabolite M2 Oxidation - Oxidationn LY-2484595 [1]
MR003759 LY-450139 LY-2484595 Metabolite M2 Unclear LY-450139 [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003748 LY-2484595 Metabolite M2 LY-2484595 Metabolite M1 Unclear LY-2484595 [1]
MR003751 LY-2484595 Metabolite M2 LY-2484595 Metabolite M20 Oxidation - Oxidationn LY-2484595 [1]
MR003760 LY-2484595 Metabolite M2 LY-2484595 Metabolite M30 Conjugation - Glucuronidation LY-450139 [2]
References
1 Evacetrapib: in?vitro and clinical disposition, metabolism, excretion, and assessment of drug interaction potential with strong CYP3A and CYP2C8 inhibitors
2 Disposition and metabolism of semagacestat, a {gamma}-secretase inhibitor, in humans. Drug Metab Dispos. 2010 Apr;38(4):554-65.

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