Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003850)
Formula
SVG example
Reactant UDCA Product LCA
Reactant Info Product Info
Metabolic Enzyme 7beta-dehydroxylase (DEH7B) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003848 Bile acid UDCA Unclear Bile acid [1]
MR011808 NCX-1000 UDCA Unclear - Unclear NCX-1000 [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003849 UDCA Beta-MCA Unclear Bile acid [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003853 Bile acid LCA Unclear Bile acid [1]
MR002540 Chenodeoxycholic acid Lithocholic acid Unclear Chenodeoxycholic acid [3]
MR002483 Ursodeoxycholic acid Lithocholic acid Unclear Ursodeoxycholic acid [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003851 LCA Hyodexycholic acid Unclear Bile acid [1]
MR003852 LCA Murideoxycholic acid Unclear Bile acid [1]
References
1 Bile Acid Metabolism in Liver Pathobiology
2 Treatment of portal hypertension with NCX-1000, a liver-specific NO donor. A review of its current status
3 Identification of human hepatic cytochrome p450 enzymes involved in the biotransformation of cholic and chenodeoxycholic acid. Drug Metab Dispos. 2008 Oct;36(10):1983-91.
4 Pharmacology of ursodeoxycholic acid, an enterohepatic drug Scand J Gastroenterol Suppl. 1994;204:1-15. doi: 10.3109/00365529409103618.

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