Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003921)
Formula Reactant H3B-6545 Product M/Z457
Reactant Info Product Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003925 H3B-6545 H3B-108945 Oxidation - N-demethylation H3B-6545 [1]
MR003924 H3B-6545 M/Z582 Unclear H3B-6545 [1]
MR003926 H3B-6545 M/Z584 Unclear H3B-6545 [1]
MR003927 H3B-6545 M/Z771 Unclear H3B-6545 [1]
MR003928 H3B-6545 M/Z875 Unclear H3B-6545 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003922 M/Z457 M/Z458 Oxidation - Oxidationn deamination H3B-6545 [1]
References
1 Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160.

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