Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR003926)
Formula Reactant H3B-6545 Product M/Z584
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003925 H3B-6545 H3B-108945 Oxidation - N-demethylation H3B-6545 [1]
MR003921 H3B-6545 M/Z457 Oxidation - N-dealkylation H3B-6545 [1]
MR003924 H3B-6545 M/Z582 Unclear H3B-6545 [1]
MR003927 H3B-6545 M/Z771 Unclear H3B-6545 [1]
MR003928 H3B-6545 M/Z875 Unclear H3B-6545 [1]
References
1 Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160.

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