Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004038)
Formula Reactant SQ-109 Product M/Z 347
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Epoxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004040 SQ-109 SQ-109 Metabolite M1 Oxidation - N-Nitrosylation SQ-109 [1]
MR004043 SQ-109 SQ-109 Metabolite M2-1 Oxidation - Ring oxidation SQ-109 [1]
MR004041 SQ-109 SQ-109 Metabolite M3 Oxidation - N-Nitrosylation SQ-109 [1]
MR004042 SQ-109 SQ-109 Metabolite M4 Oxidation - N-Dealkylation SQ-109 [1]
MR004045 SQ-109 SQ-109 Metabolite M4-1 Oxidation - Ring oxidation; N-hydroxylation SQ-109 [1]
MR004044 SQ-109 SQ-109 Metabolite M4-2 Multi-steps Reaction - Ring oxidation; Epoxidation; rearrangement SQ-109 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004039 M/Z 347 SQ-109 Metabolite M2-2 Other reaction - Rearrangement reaction SQ-109 [1]
References
1 Interspecies pharmacokinetics and in vitro metabolism of SQ109. Br J Pharmacol. 2006 Mar;147(5):476-85.

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