Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004046)
Formula Reactant SSR-97193 Product Mono-N-demethyl ferroquine
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004050 SSR-97193 4-amino-7 chloroquinoline Unclear SSR-97193 [1]
MR004048 SSR-97193 7-chloro-4-(2-hydroxymethylferrocenylmethyl) aminoquinoline Unclear SSR-97193 [1]
MR004052 SSR-97193 SSR-97193 Metabolite D Oxidation - N-oxidation SSR-97193 [1]
MR004051 SSR-97193 SSR-97193 Metabolite E Oxidation - Hydrolyzationn SSR-97193 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004047 Mono-N-demethyl ferroquine Di-N-demethyl ferroquine Unclear SSR-97193 [1]
References
1 In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum. Drug Metab Dispos. 2006 Apr;34(4):667-82.

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