Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004090)
Formula
SVG example
N-demethylation
Reactant Cocaine Product Cocaine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004074 Cocaine BE Unclear Cocaine [1]
MR004083 Cocaine Benzoylecgonine Spontaneous - Spontaneous Cocaine [1], [2]
MR004085 Cocaine Cocaethylene Unclear Cocaine [1]
MR004093 Cocaine Cocaine-N-oxide Oxidation - Oxidationn Cocaine [1]
MR004079 Cocaine Ecgonine methyl ester Unclear Cocaine [1], [2]
MR004091 Cocaine M-Hydroxycocaine Oxidation - Oxidationn Cocaine [1]
MR004087 Cocaine Norcocaine Unclear Cocaine [1]
MR004092 Cocaine p-Hydroxycocaine Oxidation - Oxidationn Cocaine [1]
References
1 Liquid chromatography--tandem mass spectrometry analysis of cocaine and its metabolites from blood, amniotic fluid, placental and fetal tissues: study of the metabolism and distribution of cocaine in pregnant rats
2 Accelerating cocaine metabolism as an approach to the treatment of cocaine abuse and toxicity

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