Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004645)
Formula
SVG example
1-hydroxylation
Reactant Ibuprofen Product 1-hydroxyibuprofen
Reactant Info Product Info
Metabolic Type Oxidation - 1-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004644 Ibuprofen 2-Hydroxyibuprofen Oxidation - 2-hydroxylation Ibuprofen [1]
MR004641 Ibuprofen 3-Hydroxyibuprofen Oxidation - 3-hydroxylation Ibuprofen [1]
MR004643 Ibuprofen Ibuprofen glucuronide Conjugation - O-glucuronidation Ibuprofen [2], [1]
MR004632 Ibuprofen Ibuprofen Metabolite M1 Unclear Ibuprofen [3]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
3 Genetic Characterization of the Ibuprofen-Degradative Pathway of Rhizorhabdus wittichii MPO218

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.