Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004641)
Formula
CYP2C8 ...
SVG example
3-hydroxylation
Reactant Ibuprofen Product 3-Hydroxyibuprofen
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - 3-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004645 Ibuprofen 1-hydroxyibuprofen Oxidation - 1-hydroxylation Ibuprofen [1]
MR004644 Ibuprofen 2-Hydroxyibuprofen Oxidation - 2-hydroxylation Ibuprofen [2]
MR004643 Ibuprofen Ibuprofen glucuronide Conjugation - O-glucuronidation Ibuprofen [1], [2]
MR004632 Ibuprofen Ibuprofen Metabolite M1 Unclear Ibuprofen [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010035 Dexibuprofen 3-Hydroxyibuprofen Unclear - Unclear Dexibuprofen [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004642 3-Hydroxyibuprofen Carboxy-ibuprofen Oxidation - Dehydrogenation Ibuprofen [1], [2]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Genetic Characterization of the Ibuprofen-Degradative Pathway of Rhizorhabdus wittichii MPO218
4 DrugBank(Pharmacology-Metabolism):Dexibuprofen

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