Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004727)
Formula
CYP3A4 ...
SVG example
Hydrolyzationn
Reactant Metronidazole Product 2-hydroxymetronidazole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004729 Metronidazole 1-acetic acid-2-methyl Oxidation - Oxidationn Metronidazole [1], [2]
MR004732 Metronidazole 2-carboxylic Oxidation - Oxidationn Metronidazole [2]
MR004728 Metronidazole 2-hydroxymethyl Oxidation - Oxidationn Metronidazole [2]
MR004734 Metronidazole 5-amino Reduction - Reduction Metronidazole [2]
MR004726 Metronidazole Acetamide Reduction - Reduction Metronidazole [2]
MR004730 Metronidazole Metronidazole Metabolite XI Oxidation - Oxidationn Metronidazole [2]
MR004731 Metronidazole Metronidazole Metabolite XII Oxidation - Oxidationn Metronidazole [2]
MR004733 Metronidazole Metronidazole Metabolite XIII Oxidation - Oxidationn Metronidazole [2]
MR004725 Metronidazole N-(2-hydroxyethyl)-oxamic acid Reduction - Reduction Metronidazole [2]
References
1 Disposition and metabolism of metronidazole in patients with liver failure
2 Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms

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