General Information of This Metabolic Reaction (MR) (ID: MR004803)
Formula Reactant Montelukast sodium Product Montelukast ether glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004802 Montelukast sodium 25-OH Montelukast Unclear Montelukast sodium [1]
MR004796 Montelukast sodium Montelukast 1, 2-Diol Oxidation - Aliphatic hydroxylation Montelukast sodium [2]
MR004798 Montelukast sodium Montelukast metabolite M1 Conjugation - O-glucuronidation Montelukast sodium [2], [1]
MR004799 Montelukast sodium Montelukast metabolite M2a/b Unclear Montelukast sodium [2]
MR004800 Montelukast sodium Montelukast metabolite M5a Oxidation - Hydrolyzationn Montelukast sodium [2], [1]
MR004801 Montelukast sodium Montelukast metabolite M5b Oxidation - Hydrolyzationn Montelukast sodium [2], [1]
References
1 In vitro metabolism of montelukast by cytochrome P450s and UDP-glucuronosyltransferases. Drug Metab Dispos. 2015 Dec;43(12):1905-16.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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