Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004824)
Formula
UGT1A8 ...
SVG example
O-glucuronidation
Reactant Mycophenolic acid Product Mycophenolic acid glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A7 (UGT1A7) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Conjugation - O-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004823 Mycophenolic acid 6-O-desmethyl-mycophenolic acid Oxidation - Demethylation Mycophenolic acid [1], [2]
MR004822 Mycophenolic acid Mycophenolic acid-acyl glucuronide Conjugation - Glucuronidation Mycophenolic acid [1], [3], [4]
MR004812 Mycophenolic acid 6-O-desmethyl-MPA (DM-MPA) Unclear Mycophenolate mofetil [5]
MR004814 Mycophenolic acid 7-O-MPA glucoside Unclear Mycophenolate mofetil [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004815 Mycophenolate mofetil Mycophenolic acid glucuronide Conjugation - Glucuronidation Mycophenolate mofetil [6]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Characterization of a phase 1 metabolite of mycophenolic acid produced by CYP3A4/5. Ther Drug Monit. 2004 Dec;26(6):600-8.
3 Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism. Drug Metab Dispos. 2005 Jan;33(1):139-46.
4 Pharmacokinetics of mycophenolic acid and its phenolic-glucuronide and ACYl glucuronide metabolites in stable thoracic transplant recipients
5 DrugBank(Pharmacology-Metabolism):Mycophenolate mofetil
6 PharmGKB summary: mycophenolic acid pathway. Pharmacogenet Genomics. 2014 Jan;24(1):73-9.

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