Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004812)
Formula Reactant Mycophenolic acid Product 6-O-desmethyl-MPA (DM-MPA)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004823 Mycophenolic acid 6-O-desmethyl-mycophenolic acid Oxidation - Demethylation Mycophenolic acid [1], [2]
MR004824 Mycophenolic acid Mycophenolic acid glucuronide Conjugation - O-glucuronidation Mycophenolic acid [1], [3]
MR004822 Mycophenolic acid Mycophenolic acid-acyl glucuronide Conjugation - Glucuronidation Mycophenolic acid [1], [4], [5]
MR004814 Mycophenolic acid 7-O-MPA glucoside Unclear Mycophenolate mofetil [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004813 6-O-desmethyl-MPA (DM-MPA) Desmethyl-MPA glucuronides Unclear Mycophenolate mofetil [7]
References
1 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
2 Characterization of a phase 1 metabolite of mycophenolic acid produced by CYP3A4/5. Ther Drug Monit. 2004 Dec;26(6):600-8.
3 The main role of UGT1A9 in the hepatic metabolism of mycophenolic acid and the effects of naturally occurring variants
4 Identification of the UDP-glucuronosyltransferase isoforms involved in mycophenolic acid phase II metabolism. Drug Metab Dispos. 2005 Jan;33(1):139-46.
5 Pharmacokinetics of mycophenolic acid and its phenolic-glucuronide and ACYl glucuronide metabolites in stable thoracic transplant recipients
6 DrugBank(Pharmacology-Metabolism):Mycophenolate mofetil
7 Mycophenolate mofetil in organ transplantation: focus on metabolism, safety and tolerability

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