Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004838)
Formula
SVG example
O-demethylation
Reactant Nabumetone Product 4-(6-Hydroxy-2-naphthyl)- butan-2-one
Reactant Info Product Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004825 Nabumetone 3-OH-nabumetone Oxidation - Hydrolyzationn Nabumetone [1], [2], [3], [4], [5]
MR004832 Nabumetone 4-(6-Methoxy-2-naphthyl)- butan-2-ol Reduction - Reduction Nabumetone [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004839 4-(6-Hydroxy-2-naphthyl)- butan-2-one 4-(6-hydroxy-2-naphthyl)- butan-2-ol Reduction - Reduction Nabumetone [3]
MR004846 4-(6-Hydroxy-2-naphthyl)- butan-2-one 4-(6-Hydroxy-2-naphthyl)- butan-2-one glucuronide Conjugation - O-glucuronidation Nabumetone [3]
MR004849 4-(6-Hydroxy-2-naphthyl)- butan-2-one 4-(6-Hydroxy-2-naphthyl)- butan-2-one sulfate Conjugation - Sulfonation Nabumetone [3]
References
1 Reductive metabolism of nabumetone by human liver microsomal and cytosolic fractions: exploratory prediction using inhibitors and substrates as marker probes. Eur J Drug Metab Pharmacokinet. 2015 Jun;40(2):127-35.
2 Analytical power of LLE-HPLC-PDA-MS/MS in drug metabolism studies: identification of new nabumetone metabolites
3 Clinical pharmacokinetics of nabumetone. The dawn of selective cyclo-oxygenase-2 inhibition?
4 A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes. Drug Metab Dispos. 2009 May;37(5):1017-24.
5 Identification of combined conjugation of nabumetone phase I metabolites with glucuronic acid and glycine in minipig biotransformation using coupling high-performance liquid chromatography with electrospray ionization mass spectrometry

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