Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004825)
Formula
HSD11B1 ...
SVG example
Hydrolyzationn
Reactant Nabumetone Product 3-OH-nabumetone
Reactant Info Product Info
Metabolic Enzyme Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info
Aldo-keto reductase 1C1 (AKR1C1) DME Info
Aldo-keto reductase 1C3 (AKR1C3) DME Info
DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004838 Nabumetone 4-(6-Hydroxy-2-naphthyl)- butan-2-one Oxidation - O-demethylation Nabumetone [1]
MR004832 Nabumetone 4-(6-Methoxy-2-naphthyl)- butan-2-ol Reduction - Reduction Nabumetone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004840 3-OH-nabumetone 6-methoxy-2-naphthylacetic acid Oxidation - Dealkylation Nabumetone [1]
MR004826 3-OH-nabumetone O-desmethyl-3-hydroxy-nabumetone Oxidation - O-demethylation Nabumetone [2]
MR004830 3-OH-nabumetone Reduced 3-hydroxy-nabumetone Reduction - Reduction Nabumetone [2]
References
1 Clinical pharmacokinetics of nabumetone. The dawn of selective cyclo-oxygenase-2 inhibition?
2 Analytical power of LLE-HPLC-PDA-MS/MS in drug metabolism studies: identification of new nabumetone metabolites

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