Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR004920)
Formula Reactant 2-phthalimidoglutaric acid Product 2-(o-carboxybenzamido)glutaric acid
Reactant Info Product Info
Metabolic Enzyme Nonenzymatical (Non-ME) DME Info
Metabolic Type Conjugation - Amide Hydrolyation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004924 2-phthalimidoglutaramic acid 2-phthalimidoglutaric acid Conjugation - Amide Hydrolyation Thalidomide [1]
MR004919 4-phthalimidoglutaramic acid 2-phthalimidoglutaric acid Conjugation - Amide Hydrolyation Thalidomide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014136 2-(o-carboxybenzamido)glutaramic acid 2-(o-carboxybenzamido)glutaric acid Conjugation - Amide Hydrolyation Thalidomide [1]
MR004916 4-(o-carboxybenzamido)glutaramic acid 2-(o-carboxybenzamido)glutaric acid Conjugation - Amide Hydrolyation Thalidomide [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004917 2-(o-carboxybenzamido)glutaric acid Glutamic acid Conjugation - Amide Hydrolyation Thalidomide [2]
MR014138 2-(o-carboxybenzamido)glutaric acid L-Glutamine Conjugation - Amide Hydrolyation Thalidomide [2]
MR004918 2-(o-carboxybenzamido)glutaric acid Phthalic Acid Conjugation - Amide Hydrolyation Thalidomide [2]
References
1 Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites
2 Thalidomide metabolism and hydrolysis: mechanisms and implications

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