Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005019)
Formula
SVG example
Glucuronidation
Reactant Fluoxetine hydrochloride Product Fluoxetine glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2A1 (UGT2A1) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005018 Fluoxetine hydrochloride 4-Trifluoromethylphenol Oxidation - O-dealkylation Fluoxetine hydrochloride [1], [2]
MR005012 Fluoxetine hydrochloride Norfluoxetine Oxidation - N-demethylation Fluoxetine hydrochloride [3], [4], [5], [2]
References
1 O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes. J Pharmacol Exp Ther. 2002 Jan;300(1):105-11.
2 Simultaneous identification and quantitation of fluoxetine and its metabolite, norfluoxetine, in biological samples by GC-MS
3 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
4 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
5 (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Oct;28(10):1187-91.

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