Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005012)
Formula
CYP2D6 ...
SVG example
N-demethylation
Reactant Fluoxetine hydrochloride Product Norfluoxetine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005018 Fluoxetine hydrochloride 4-Trifluoromethylphenol Oxidation - O-dealkylation Fluoxetine hydrochloride [1], [2]
MR005019 Fluoxetine hydrochloride Fluoxetine glucuronide Conjugation - Glucuronidation Fluoxetine hydrochloride [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005013 Norfluoxetine 4-Trifluoromethylphenol Oxidation - O-dealkylation Fluoxetine hydrochloride [4]
MR005015 Norfluoxetine Norfluoxetine alcohol Oxidation - Oxidationn deamination Fluoxetine hydrochloride [3]
MR005017 Norfluoxetine Norfluoxetine glucuronide Conjugation - Glucuronidation Fluoxetine hydrochloride [5]
References
1 O-Dealkylation of fluoxetine in relation to CYP2C19 gene dose and involvement of CYP3A4 in human liver microsomes. J Pharmacol Exp Ther. 2002 Jan;300(1):105-11.
2 Simultaneous identification and quantitation of fluoxetine and its metabolite, norfluoxetine, in biological samples by GC-MS
3 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
4 DrugBank(Pharmacology-Metabolism):Fluoxetine hydrochloride
5 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.

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