Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005125)
Formula Reactant Hydrocortisone Product Tetrahydrocortisol Glucuronide 2
Reactant Info Product Info
Metabolic Type Conjugation - O-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005128 Hydrocortisone Cortisone Oxidation - Oxidationn Hydrocortisone [1], [2]
MR005124 Hydrocortisone Tetrahydrocortisol Glucuronide 1 Conjugation - O-glucuronidation Hydrocortisone [2]
MR005126 Hydrocortisone Tetrahydrocortisone Glucuronide 1 Conjugation - O-glucuronidation Hydrocortisone [2]
MR005127 Hydrocortisone Tetrahydrocortisone Glucuronide 2 Conjugation - O-glucuronidation Hydrocortisone [2]
References
1 Cortisol metabolism in healthy young adults: sexual dimorphism in activities of A-ring reductases, but not 11beta-hydroxysteroid dehydrogenases
2 Metabolite profiling and pharmacokinetic evaluation of hydrocortisone in a perfused three-dimensional human liver bioreactor

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