Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005161)
Formula
SVG example
N-oxidation
Reactant M2 (piperaquine) Product M5 (piperaquine)
Reactant Info Product Info
Metabolic Type Oxidation - N-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005160 Piperaquine M2 (piperaquine) Oxidation - N-oxidation Piperaquine [1], [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005162 M2 (piperaquine) Piperaquine metabolite M6 Unclear Piperaquine [1], [2]
References
1 Characterization of human urinary metabolites of the antimalarial piperaquine
2 Metabolite identification of the antimalarial piperaquine in vivo using liquid chromatography-high-resolution mass spectrometry in combination with multiple data-mining tools in tandem
3 In vitro metabolism of piperaquine is primarily mediated by CYP3A4

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