Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005160)
Formula
SVG example
N-oxidation
Reactant Piperaquine Product M2 (piperaquine)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005163 Piperaquine Byproduct (piperaquine) Oxidation - N-dealkylation Piperaquine [1], [2]
MR005165 Piperaquine M1 (piperaquine) Oxidation - N-dealkylation Piperaquine [1], [2]
MR005168 Piperaquine M3 (piperaquine) Oxidation - Hydrolyzationn Piperaquine [1]
MR005167 Piperaquine M7 (piperaquine) Oxidation - Hydrolyzationn Piperaquine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005161 M2 (piperaquine) M5 (piperaquine) Oxidation - N-oxidation Piperaquine [1], [2]
MR005162 M2 (piperaquine) Piperaquine metabolite M6 Unclear Piperaquine [1], [2]
References
1 Characterization of human urinary metabolites of the antimalarial piperaquine
2 Metabolite identification of the antimalarial piperaquine in vivo using liquid chromatography-high-resolution mass spectrometry in combination with multiple data-mining tools in tandem

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