Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005168)
Formula Reactant Piperaquine Product M3 (piperaquine)
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005163 Piperaquine Byproduct (piperaquine) Oxidation - N-dealkylation Piperaquine [1], [2]
MR005165 Piperaquine M1 (piperaquine) Oxidation - N-dealkylation Piperaquine [1], [2]
MR005160 Piperaquine M2 (piperaquine) Oxidation - N-oxidation Piperaquine [1], [2], [3]
MR005167 Piperaquine M7 (piperaquine) Oxidation - Hydrolyzationn Piperaquine [1]
References
1 Characterization of human urinary metabolites of the antimalarial piperaquine
2 Metabolite identification of the antimalarial piperaquine in vivo using liquid chromatography-high-resolution mass spectrometry in combination with multiple data-mining tools in tandem
3 In vitro metabolism of piperaquine is primarily mediated by CYP3A4

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