Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005172)
Formula Reactant Pirprofen Product Pirprofen glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005176 Pirprofen Amino-metabolite Unclear Pirprofen [1]
MR005169 Pirprofen Epoxide metabolite Unclear Pirprofen [1]
MR005174 Pirprofen Pyrrole M1 Unclear Pirprofen [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005173 Pirprofen glucuronide Pyrrole metabolite glucuronide Unclear Pirprofen [1], [2]
References
1 High-performance liquid chromatographic determination of pirprofen and five of its metabolites in human plasma without hydrolysis and in human urine before and after chemical hydrolysis
2 Glucuronidation of 2-arylpropionic acids pirprofen, flurbiprofen, and ibuprofen by liver microsomes. Drug Metab Dispos. 1990 Sep-Oct;18(5):692-7.

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