Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005218)
Formula
SVG example
O-dealkylation
Reactant Reboxetine Product Reboxetine metabolite C
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005214 Reboxetine Reboxetine metabolite A Oxidation - Hydrolyzationn Reboxetine [1], [2]
MR005216 Reboxetine Reboxetine metabolite B Oxidation - Hydrolyzationn Reboxetine [1], [2]
MR005220 Reboxetine Reboxetine metabolite D Oxidation - Oxidationn Reboxetine [1], [2]
MR005221 Reboxetine Reboxetine metabolite E Oxidation - Oxidationn Reboxetine [1], [2]
MR005222 Reboxetine Reboxetine metabolite I Unclear Reboxetine [1], [2]
MR005223 Reboxetine Reboxetine metabolite L Unclear Reboxetine [1], [2]
MR005224 Reboxetine Reboxetine metabolite M Unclear Reboxetine [1], [2]
MR005225 Reboxetine Reboxetine metabolite N Unclear Reboxetine [1], [2]
MR005226 Reboxetine Reboxetine metabolite O Unclear Reboxetine [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005219 Reboxetine metabolite C Reboxetine metabolite H Oxidation - Oxidationn Reboxetine [1], [2]
References
1 Comparison of the disposition and of the metabolic pattern of Reboxetine, a new antidepressant, in the rat, dog, monkey and man
2 Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression. Clin Pharmacokinet. 2000 Dec;39(6):413-27.

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