Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005294)
Formula
UGT1A7 ...
SVG example
Glucuronidation
Reactant Cis-4-hydroxytamoxifen Product Cis-4-hydroxytamoxifen-O-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A7 (UGT1A7) DME Info
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005295 Cis-4-hydroxytamoxifen Endoxifen Oxidation - N-demethylation Cis-4-hydroxytamoxifen [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003524 Alpha-hydroxytamoxifen Alpha-hydroxytamoxifen glucuronide Conjugation - Sulfation Tamoxifen citrate [2]
References
1 Tamoxifen dose and serum concentrations of tamoxifen and six of its metabolites in routine clinical outpatient care
2 PharmGKB:Tamoxifen citrate

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