Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005295)
Formula
CYP3A5 ...
SVG example
N-demethylation
Reactant Cis-4-hydroxytamoxifen Product Endoxifen
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005294 Cis-4-hydroxytamoxifen Cis-4-hydroxytamoxifen-O-glucuronide Conjugation - Glucuronidation Cis-4-hydroxytamoxifen [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR003530 4-hydroxytamoxifen Endoxifen Conjugation - Sulfation Tamoxifen citrate [2]
MR003516 N-Desmethyltamoxifen Endoxifen Oxidation - 4-Hydroxylation Tamoxifen citrate [2]
MR003529 4-hydroxytamoxifen sulfate Endoxifen Conjugation - Sulfation Tamoxifen citrate [2]
References
1 Glucuronidation of active tamoxifen metabolites by the human UDP glucuronosyltransferases. Drug Metab Dispos. 2007 Nov;35(11):2006-14.
2 PharmGKB:Tamoxifen citrate

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