Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005302)
Formula
SVG example
Hydrolyzationn
Reactant Cotinine Product 3'-hydroxycotinine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2A5 (Cyp2a5) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005303 Cotinine Cotinine-N-glucuronide Conjugation - Glucuronidation Cotinine [1]
MR005305 Cotinine Cotinine-N-oxide Oxidation - Oxdation Cotinine [2]
MR005304 Cotinine Norcotinine Oxidation - N-demethylation Cotinine [1]
MR005300 Cotinine Trans-3'-hydroxycotinine Oxidation - Hydrolyzationn Cotinine [1]
MR002964 Cotinine Cotinine glucuronide metabolite Conjugation - Glucuronidation Nicotine [3]
MR002967 Cotinine Cotinine N-oxide metabolite Oxidation - N-Oxidation Nicotine [3]
MR002968 Cotinine Nicotine-1'-N-oxide Oxidation - 1'-N-Oxidation Nicotine [3]
MR002965 Cotinine Nornicotine Unclear Nicotine [4]
References
1 Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation
2 Increased cotinine elimination and cotinine-N-oxide formation by phenobarbital induction in rat and mouse
3 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
4 DrugBank(Pharmacology-Metabolism)Nicotine

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