Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR005304)
Formula
SVG example
N-demethylation
Reactant Cotinine Product Norcotinine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2A6 (CYP2A6) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005302 Cotinine 3'-hydroxycotinine Oxidation - Hydrolyzationn Cotinine [1], [2]
MR005303 Cotinine Cotinine-N-glucuronide Conjugation - Glucuronidation Cotinine [3]
MR005305 Cotinine Cotinine-N-oxide Oxidation - Oxdation Cotinine [4]
MR005300 Cotinine Trans-3'-hydroxycotinine Oxidation - Hydrolyzationn Cotinine [3]
MR002966 Cotinine 3'-hydroxycotinine Oxidation - 3'-Hydroxylation Nicotine [5]
MR002964 Cotinine Cotinine glucuronide metabolite Conjugation - Glucuronidation Nicotine [5]
MR002967 Cotinine Cotinine N-oxide metabolite Oxidation - N-Oxidation Nicotine [5]
MR002968 Cotinine Nicotine-1'-N-oxide Oxidation - 1'-N-Oxidation Nicotine [5]
MR002965 Cotinine Nornicotine Unclear Nicotine [6]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002956 Nicotine Norcotinine Unclear Nicotine [6]
References
1 Characterization and comparison of nicotine and cotinine metabolism in vitro and in vivo in DBA/2 and C57BL/6 mice
2 Metabolism of nicotine and cotinine by human cytochrome P450 2A13. Drug Metab Dispos. 2005 Feb;33(2):258-61.
3 Interindividual variability in nicotine metabolism: C-oxidation and glucuronidation
4 Increased cotinine elimination and cotinine-N-oxide formation by phenobarbital induction in rat and mouse
5 Pharmacogenomics knowledge for personalized medicine Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
6 DrugBank(Pharmacology-Metabolism)Nicotine

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